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Search Results for " topoisomerase iiα "

10

Compounds

Cat No. Product Name Synonyms Targets
T36968 ARN-21934 Topoisomerase
ARN-21934 is a potent, highly selective, blood-brain barrier (BBB) penetrant inhibitor for human topoisomerase II α over β. ARN-21934 inhibits DNA relaxation with an IC50 of 2 μM as compared to the anticancer agent Etopo...
T62224 Topoisomerase IIα-IN-2
Topoisomerase IIα-IN-2 (compound 5) is a DNA-binding ligands and a potent inhibitor of the topoisomerase TopoIIα. Topoisomerase IIα-IN-2 exhibits high anti-proliferative activity in human cancer cell lines. Topoisomerase...
T63594 Topoisomerase IIα-IN-3
Topoisomerase IIα-IN-3 is a DNA-inserting topoisomerase-Iiα inhibitor that blocks the cell cycle in G0/G1 phase and induces apoptosis.
T62223 Topoisomerase IIα-IN-1
Topoisomerase IIα-IN-1 (compound 2) is a DNA-binding ligands and a potent inhibitor of TopoIIα, a topoisomerase. topoisomerase IIα-IN-1 shows good anti-proliferative effects on human cancer cell lines.
T61431 Topoisomerase IIα-IN-4
Topoisomerase IIα-IN-4 (F2) is a non-intercalative ATP-competitive inhibitor of human DNA topoisomerase II, specifically inhibiting TopoIIα with an IC50 value of 3.8 μM and TopoIIβ with an IC50 value of 10.1 μM. It demon...
T61283 Topoisomerase II inhibitor 3
Topoisomerase II inhibitor 3 (Compound 6 h) is an acridone derivative that acts as a Type II DNA topoisomerase (topo II) inhibitor. It specifically inhibits the topo IIα/β subtypes, with an IC50 value of 0.17 μM for topo...
T79978 6,6′-Dihydroxythiobinupharidine
6,6′-Dihydroxythiobinupharidine, a cysteine proteases inhibitor, amplifies DNA cleavage facilitated by human topoisomerase IIα and IIβ by approximately 8-fold and 3-fold, respectively [1] [2].
TN5133 3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone HIV Protease , Topoisomerase
5,7,3',5'-tetrahydroxy-6,4'-dimethoxyflavone exhibits anti-HIV-1 activity in the anti-syncytium assay using (∆Tat/rev)MC99 virus and 1A2 cell line system, it shows considerably activity against HIV-1 reverse transcriptas...
T72157 Topoisomerase II inhibitor 7
Topoisomerase II inhibitor 7, a potent inhibitor of the topoisomerase II alpha subtype, exhibits an IC50 of 3.19 μM. It effectively induces cell cycle arrest and apoptosis.
T36695 TAS-103
TAS-103 is a dual inhibitor of DNA topoisomerase I/II, used for cancer research. TAS-103 is a dual inhibitor of DNA topoisomerase I/II. TAS-103 (0.1-10 μM) is active on CCRF-CEM cells, with an IC50 value of 5 nM. TAS-103...
TargetMol